Hey guys, I have been enjoying Ali Macofsky’s and Andrew Santino’s comedy and started wondering if they’re related. Does anyone know if there’s any family connection between them? 
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Yes, Ali Macofsky and Andrew Santino are indeed related. Ali Macofsky is Andrew Santino’s sister. Both siblings share a passion for comedy, with Andrew being a well-established comedian and Ali making a name for herself as an emerging talent in the comedy scene.